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    • 专利摘要:
    Pharmaceutical composition based on ozonized marigold oil, procedure for its preparation and uses. It is made up of 5% by weight of calendula oleate (calendula officinalis) and 95% by weight of virgin olive oil bio (olea europeae), being a preparation of ph 5, with the appearance of a yellow-orange liquid oil, with a stability of 12 months once the container is opened and kept in good condition, the container being well closed, in a cool place, at a temperature below 25ºc, dry and protected from light, and being a clear, orange liquid, with slight characteristic density odor: 0.917 - 0.923 g/ml. And refractive index: 1.4710 - 1.4770. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2568701A1
    申请号:ES201400860
    申请日:2014-10-31
    公开日:2016-05-03
    发明作者:Inmaculada MORENO FERNÁNDEZ；Miriam D. DÍAZ CASTAÑAR；Nora LIECHTENSTEIN
    申请人:Jara 10 S L；Jara 10 SL；
    IPC主号:
    专利说明:

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    DESCRIPTION
    Pharmaceutical composition based on ozonized calendula oil, procedure for obtaining and uses.
    Object of the invention
    The present invention relates to a pharmaceutical preparation based on ozonized calendula oil according to a standard formula of calendula oleate (Calendula officinalis olea Europea) in 100% organic olive oil. Calendula oil has antiseptic properties against staphylococcus, parasiticides against Trichomonas, antiedematous, anti-inflammatory, decongestant, healing, emollient, epithelializing and toning.
    Calendula oil also softens sensitive skin and skin with a tendency to redness.
    Preparations with calendula oil are especially suitable for sensitive, infantile and slightly damaged skin (e.g. by solar erythema). It is also used as a fluidizing element in creams.
    It is generally used between 2 and 1.0%. For example, 3% for day creams, night creams, cleansers, moisturizers, for the legs, sunscreen, beauty, body, facial, beauty, herbal milks, lip care products, (gloss, pencils) ; 4% in vitamin creams, and protective; 5% in infant creams, after-sun, body oils, make-up removers, and sunscreen sprays.
    It is heat labile and photosensitive.
    Its industrial application falls within the technical field of the elaboration of topical compounds for pharmaceutical use and more particularly, in the calendula oil manufacturing industry.
    Background of the invention
    It has been known since ancient times the ozonized ointment calendula oleate (Calendula officinalis olea Europea) whose procedure to obtain it is to macerate the calendula flowers in the olive oil, leaving the flower extract in the oil that is subsequently filtered, containing the oil essential (alpha-bisabolol), flavonoids derived from quercetol and isoramnetol, very abundant carotenoids, mucllagos, tannins, principles - bitter, and triterpenic saponins. However, ozonized calendula oil is not known, which advantageously lends the following properties to the pharmaceutical compound:
    - To the soothing and hydrating capacity of this oil is added the great germicidal power of ozone, achieving a dermal regeneration
    - It also achieves the elimination of viruses, bacteria, fungi and other pathogens that may be present on the skin.
    - It also has a great regenerative power of the skin, thanks to its power to capture free radicals by oxygenation.
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    Although no identical invention has been found to that described, we present below found documents that reflect the state of the art related to it.
    Thus, document ES2281651T3 refers to a water-in-oil microemulsion, characterized in that it lacks crosslinking and has
    a) 45 to 90% by weight of a liquid oil phase,
    b) 5 to 40% by weight of a mixture consisting of one or more non-ionic water / oil surfactants with an HLB value of 3 to 7 and one or more non-ionic oil / water surfactants with an HLB value of 9 to 18 in a ratio of 1: 4 to 1: 1,2;
    c) 0.01 to 20% by weight of one or more phospholipids, cholesterol or cholesterol derivatives,
    d) 0.00 to 15% by weight of one or more mono- or difunctional C1-8 alcohols and
    e) 1 to 1 0% by weight of water or aqueous solutions, the micelles of this primary microemulsion having a particle size of 20 to 400 nm and the emulsion can optionally be converted into a secondary water / oil microemulsion or a oil / water microemulsion by reaction with an aqueous phase. Unlike the proposed invention, it is made from water in oil, and not exclusively from oil.
    ES2327156T3 proposes a topical composition to be applied to the human body, which has a viscosity of at least 500 cps and a pH from about 3 to less than 7, comprising: one or more anionic surfactants; optionally one or more alkanolamides; optionally one or more additional surfactants selected from non-ionic and amphoteric surfactants; one or more emollients; salicylic acid and / or salicylate in an amount sufficient for the compositions to be effective against both Gram-positive and Gram-negative microorganisms; one or more inorganic or organic salts soluble in water, and water.
    Document ES2217983A1 describes an agent that contains an onion extract for topical application, characterized in that it contains a fatty phase (oily), additive substances selected from consistency-giving agents, colorants, perfumes, moisture-retaining agents, antioxidants, preservatives, stabilizers, additional active substances, as well as an onion extract.
    ES2317067T3 proposes an agent for cutaneous external use, which comprises: a salt of the upper fatty acid ester of the ascorbic acid-2-phosphoric acid ester, said upper fatty acid ester being represented of the ascorbic acid-2-phosphoric acid ester, by the following formula: in which R is a residual group of an aliphatic carboxylic acid of 10 to 20 carbon atoms and a 1,2-pentanediol or 1,2-hexanediol.
    ES2269172T3 describes isolated nucleic acid, which encodes a polypeptide with desaturase activity, which transforms linoleic acid into calendula acid, chosen from the group consisting of: a) a nucleic acid with the sequence represented in SEQ ID NO: 1, b) nucleic acids, which are derived from the nucleic acids represented in SEQ ID NO: 1, as a consequence of the degenerated genetic code, c) derivatives of the nucleic acid, represented in SEQ ID NO: 1, which can be isolated by hybridization at 42 ° C in 5 x SSC and 50% formamide.
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    Document ES2252029T3 proposes cosmetic or dermatological preparations consisting of finely dispersed water-in-oil systems, which contain 1. an organic phase, 2. an aqueous phase, 3. At least a modified phyllosilicate that has both hydrophilic and lipophilic properties, that is, amphiphilic character, and at the water / oil interface, 4, at least one flavone, flavanone and / or a flavonoid, and 5, at most 0.5% by weight of one or more emulsifiers.
    Conclusions: As can be seen from the research carried out, none of the documents found solves the problems posed as the proposed invention does.
    Description of the invention
    The pharmaceutical composition based on ozonized calendula oil and its uses object of the present invention is obtained from the following procedure:
    - At least 100 grams of calendula oleate is weighed on a scale
    - In a beaker, said 100 g of calendula oleate are placed in bio virgin olive oil in a weight percentage of 5% Calendula officinalis and 95% European Olea.
    - An ionizer is placed inside the vessel and operated for 30 min that by means of discharges will transform the O2 into O3.
    - It is preferably packaged in 50 ml transparent airless and labeled according to standard.
    The result is a preparation of pH 5, with the appearance of a liquid oil of yellow-orange color, consisting of a moisturizing oil suitable for massage that has a stability of 12 months once the container is opened and kept in good condition, keeping the tightly closed container, in a cool place, at a temperature below 25 ° C, dry and protected from light. It is a fast, orange liquid with a slight characteristic odor of density: 0.917 - 0.923 g / ml, and refractive index: 1.4710 - 1.4770.
    The following tools are required for its preparation:
    - Balance, watch glasses or weighing cuvettes, spatulas, pH measuring strips, beakers and glass rods.
    - Rilice Ozonator
    - Gloves and glasses as personal protective equipment Its uses are as follows:
    - It is used in the following natural therapies for diseases or problems: acne treatment, ulcers, muscle aches, gynecological diseases such as candidiasis, insect bites, inflammation of the elbow, throat, conjutivitis, dental,
    hemorrhoids.
    - Among its most common applications in personal care and cosmetics, we can mention the make-up remover, rejuvenating treatments against wrinkles,
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    cellulite reducer, improvement of the appearance of scars, cleansing and deep hydration of the skin, protecting it from aging thanks to the capture of free radicals.
    - Other uses are the cure of cold sores, fungus and spots on the skin or soften roughness on heels, elbows and feet.
    Description of a preferred embodiment
    A preferred embodiment of the present invention can be developed from a procedure in which:
    - At least 100 grams of calendula oleate is weighed on a scale
    - 100 g of calendula oleate (Calendula officinalis) in organic virgin olive oil (Olea Europeae) are introduced into a beaker in a percentage by weight of
    or 5% calendula oleate (Calendula officinalis) and
    or 95% organic virgin olive oil (Olea Europeae).
    - An ionizer is placed inside the vessel and operated for 30 minutes, which by means of discharges will transform the O2 into O3.
    - It is preferably packaged in 50 ml transparent airless and labeled according to standard.
    The result is a preparation of pH 5, with the appearance of a liquid oil of yellow-orange color, consisting of a moisturizing oil suitable for massage that has a stability of 12 months after opening the container and keeping it in good condition, keeping the tightly closed container, in a cool place, at a temperature below 25 ° C, dry and protected from light. It is a fast, orange liquid with a slight characteristic odor of density: 0.917 - 0.923 g / ml, and refractive index: 1.4710 - 1.4770.
    The following tools are required for its preparation:
    - Balance, watch glasses or weighing cuvettes, spatulas, pH measuring strips, beakers and glass rods.
    - Rilice Ozonator
    - Gloves and glasses as personal protective equipment Its uses are as follows:
    - As a pharmaceutical preparation for use in the following natural therapies for the following diseases: treatment of acne, ulcers, muscle aches, gynecological diseases such as candidiasis, insect bites, inflammation of the elbow, throat, dental conjutivitis, hemorrhoids.
    - As a moisturizing oil, it is applied in personal care and cosmetics, being used for make-up removal, rejuvenating treatments against wrinkles, cellulite reduction, improvement of the appearance of scars, cleaning and deep hydration of the skin, protecting it from aging thanks to Free radicals uptake.
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    - Other uses are the cure of cold sores, fungus and spots on the skin or soften roughness on heels, elbows and feet.
    权利要求:
    Claims (4)
    [1]
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    1. Pharmaceutical composition based on ozonized calendula oil, characterized by being 5% by weight of calendula oleate (Calendula officinalis) and 95% by weight of bio virgin olive oil (Olea Europeae), being a preparation pH 5, with the appearance of a yellow-orange liquid oil, with a stability of 12 months once the container is opened and kept in good condition, the container being tightly closed, in a cool place, at a temperature below 25 ° C , dry and protected from light, and being a clear, orange liquid, with a slight characteristic odor of density: 0.917 - 0.923 g / ml, and refractive index: 1.4710 - 1.4770.
    [2]
    2. Procedure for obtaining the pharmaceutical composition based on ozonized calendula oil described in claim 1, characterized by being developed in the following stages:
    - At least 100 grams of calendula oleate is weighed on a scale
    - 100 g of calendula oleate (Calendula officinalis) in organic virgin olive oil (Olea Europeae) are introduced into a beaker in a percentage by weight of:
    or 5% calendula oleate (Calendula officinalis) and
    or 95% organic virgin olive oil (Olea Europeae).
    - An ionizer is placed inside the vessel and operated for 30 minutes, which by means of discharges will transform the O2 into O3.
    - It is preferably packaged in 50 ml transparent airless and labeled according to standard, the following tools being necessary for its preparation:
    - Balance, watch glasses or weighing cuvettes, spatulas, pH measuring strips, beakers and glass rods.
    - Rilice Ozonator
    - Gloves and glasses as personal protective equipment
    [3]
    3. Use of the pharmaceutical composition based on ozonized calendula oil described in claim 1, to prepare a medicament for the treatment of acne, ulcers, muscle aches, gynecological diseases, candidiasis, insect bites, swelling of the elbow, throat, Dental conjutivitis, hemorrhoids, ace! as to the cure of cold sores, fungus and spots on the skin and to smooth roughness on heels, elbows and feet.
    [4]
    4. Use of the pharmaceutical composition based on ozonized calendula oil described in claim 1, to prepare a moisturizing oil intended for personal care, and in cosmetics, it is used for makeup removal, rejuvenating treatments against wrinkles, cellulite reduction , improvement of the appearance of scars, cleansing and deep hydration of the skin, protecting it from aging thanks to the capture of free radicals.
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    同族专利:
    公开号 | 公开日
    ES2568701B1|2016-11-21|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO2020079717A1|2018-10-19|2020-04-23|Soldati Roberto|Ozonized phytotherapic composition for tissue and bone regeneration|
    法律状态:
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    ES201400860A|ES2568701B1|2014-10-31|2014-10-31|Pharmaceutical composition based on ozonized marigold oil, procedure for obtaining and uses|ES201400860A| ES2568701B1|2014-10-31|2014-10-31|Pharmaceutical composition based on ozonized marigold oil, procedure for obtaining and uses|
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